This issue of Interventional Cardiology Clinics, guest edited by Drs. William L. Lombardi and Kathleen E. Kearney, will focus on Chronic Total Occlusion. Topics discussed in this issue include, but are not limited to: Indications for percutaneous coronary intervention of CTO; Pre-procedure planning for CTO PCI; Toolbox for CTO PCI; Antegrade Wire Escalation Case Selection and Strategies; Step by Step Antegrade Dissection and Reentry and Case Selection; Retrograde Dissection and Reentry Strategies; STAR and SPM; The role of imaging in Chronic Total Occlusions; Hybrid 2.0; Perforation mechanisms, risk stratification and management in the non-post CABG patient; Perforation mechanisms, risk stratification and management in the post-CABG patient; Access selection and complications; Patient selection for hemodynamic support in High Risk PCI; Other Complications in CTO PCI; and Managing the CTO Operator.